Solid Lipid Nanoparticles (SLNs): Preparation and Properties of Calix[4]resorcinarene Derived Systems.

Solid Lipid Nanoparticles (SLNs): Preparation and Properties of Calix[4]resorcinarene Derived Systems.
February 2004
J?r?me Gualbert, Patrick Shahgaldian, Adina Lazar and Anthony W. Coleman
Journal of Inclusion Phenomena and Macrocyclic Chemistry Volume 48, Numbers 1-2 Pages: 37 - 44
You can view the abstract online. A subscription is required to view the full text or it can be purchased online.
Abstract
Solid Lipid Nanoparticles (SLNs) have been prepared romc-2,c-8,c-14,c-20 etraundecyl-4,6,10,12,16, ,22,24- octahydroxyresorc[4]areneas colloidal suspensions. Photon Correlation Spectroscopy studies revealed aparticle hydrodynamic diameter of 150 nm. Non-contact mode Atomic ForceMicroscopy allows observation of the particles as slightly flattened sphericalobjects of 236 (?40) nm diameter and 145 (?40) nm height. Thestudy of the preparation parameters showed that shear force does not affectthe hydrodynamic size of the SLNs. In contrast, the viscosity and the pH ofthe aqueous phase, the amphiphile concentration in the organic phase and thevolume of organic phase used, all lead to variation in the size of the particles.In term of post preparation parameters only the ionic strength has been shownto affect significantly the particle size; while the pH of the storing solution,microwave, ultrasonic and thermal treatments do not. Short and long-termstability studies have been performed to measure the effect of the ionic strengthon the stability of the particles. The use of carbohydrate cryoprotectants does notallow re-dispersion of the colloidal suspension after freeze-drying.